Background. Respiratory symptoms are usually underestimated in patients with chronic kidney disease undergoing maintenance\nhemodialysis. Therefore, we set out to investigate the prevalence of patients chronic dyspnea and the relationship of the symptom\nto lung function indices. Methods. Twenty-five clinically stable hemodialysis patients were included.The mMRC dyspnea scale was\napplied before and after hemodialysis. Spirometry, single breath nitrogen test, arterial blood gases, static maximum inspiratory\n(P1 max) and expiratory (Pe max) muscle pressures, and mouth occlusion pressure (P0.1) were also measured. Results. Despite normal\nspirometry, all patients (100%) reported mild to moderate degree of chronic dyspnea pre which was reduced after hemodialysis.The\nsole predictor of (?) mMRCwas the (?) P0.1 (r = 0.71, P< 0.001). The Pi max was reduced before and correlated with the duration\nof hemodialysis (r = 0.614, P < 0.001), whilst after the session it was significantly increased (P < 0.001). Finally (?) weight was\ncorrelated with the (?) Pi max %pred (P = 0.533, P = 0, 006) and with the (?) CV (%pred) (r = 0.65, P < 0.001). Conclusion.\nWe conclude that dyspnea is the major symptom among the CKD patients that improves after hemodialysis. The neuromechanical\ndissociation observed probably is one of the major pathophysiologic mechanisms of dyspnea.
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